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  • Name, indication, and route of administration
  • Frequency of administration and duration of therapy
  • How to use device and read dose markings
  • Storage and handling, including caregiver precautions
    • Hazardous Drugs
      • Wear gloves when handling the medication and all waste
      • Designate a specific area of the yard to prevent exposure of hazardous waste to others, especially children and other household pets
  • Disposal of unused drugs
    • Police departments
    • Community “Drug Take Back” events
  • Any foods or other products to avoid
    • Some medications may need to be separated by a window of two hours (or more) from any dairy products
    • Non-prescription products (OTC) can interact with the medications
      • CBD products may cause drug interactions
  • Emphasize importance of returning to DVM for recheck appointments
  • Monitor for signs of efficacy (or lack thereof) or toxicity
    • Remind of placebo effects
    • Vital signs
      • Different by species
    • Signs and symptoms can vary from those expressed by humans
      • Example: lip-smacking and inappetence may be a sign of nausea
  • Adverse event reporting — FDA Form 1932a
  • For compounded preparations
    • Explain the limitations compared to an FDA approved product
    • Monitor for any signs of instability (color, consistency, odor, animal refusing medication after initial acceptance)

Oral Administration

  • Clip nails
  • Wrap in a towel
  • Place small amount on nose to saturate the olfactory system
  • Coat capsule or tablet with small amount of butter or cream cheese
  • Follow with water or moist food (due to horizontal orientation)
    • Doxycycline (can cause esophageal stricture)
  • Create a game with medicated and non-medicated treats
  • Trial non-medicated samples
  • Mask taste with empty gelatin capsules
  • Demo video

Topical and Transdermal Application

  • Efficacy concerns
    • Lack of bioavailability
  • Topical = systemic
    • Cats are constant groomers. Regard anything topical as potentially becoming systemic.
  • Application location
    • Find an area difficult to reach so medication cannot be licked off
    • Pinna = hairless, inner part of the ear
  • Wear gloves
  • Wash hands
  • “Drying” time (1-2 hours)
    • Utilize walking
    • Avoid contact with area (monitor children and other animals)
  • Monitor for contact irritation
  • Calibration of devices

Administration of Injectable Medications

  • Intramuscular (IM) injections
    • Greater chance of damaging blood vessels, pain
    • < 5ml for big dogs
    • < 2ml for cats and small dogs
  • Injection site sarcomas
    • Rotate the injection sites in order to avoid
  • Insulin – may need to shake some formulations, don’t rub the area after injection, U-40 vs. U-100 syringes
  • Dismantling pens
    • As a cost saving measure and to avoid waste, insulin pens can be dismantled and used as if it where a smaller vial, drawing the dose up through the septum
    • Technique frequently employed with insulin glargine (Lantus)
  • General steps for administration
    • Subcutaneous fluids administration demo
    • Insulin administration demo
    • Application of continuous glucose monitor demo

Ophthalmic Medication Administration

  • Wash hands
  • May require two people
  • Solutions – one drop at a time
  • Ointment – use “rice grain” amount
  • Do not touch the tip to eye – injury and contamination risks
  • Applying solutions and ointments concurrently – solution should be applied first, followed by ointment at least 5 minutes later
  • Applying two ointment products
    • Wait 30 minutes between application of each product
    • Equine patients may have a subpalpebral lavage system (SPL) catheter in place
      • delivers topical liquid medication onto the surface of the equine cornea
      • do not use oil based formulations with these devices due to clogging potential
  • Patients may salivate if solution gets into oral cavity

Aerosolized Medication Administration

  • Nebulizers
    • May create an enclosed area with the help of an empty aquarium or by placing a towel over patient’s cage
  • Using a metered-dose inhaler with a species-specific spacer demo

Administration of Rescue Medications

  • Intranasal versus rectal administration
    • Impossible to instruct animal patient to retain suppository
  • Rectal administration
    • After the administration, you want to pull the tail down to prevent immediate expulsion
  • Intranasal administration demo