Injection Dependent Routes

Several of the "sterility demanding" routes require that a needle (or catheter) and some type of propelling device (e.g., syringe, pump, gravity fed bag) be used to place the formulation in the desired anatomical site. These can be said to be injection dependent routes.

These injection dependent routes have several characteristics in common. The formulations that can be used with injectibles are limited to solutions, suspensions, and emulsions. Many of the routes have limited volumes of formulation that can be injected; excessive injection volumes will cause pain and cell necrosis.