The Pharmaceutics and Compounding Laboratory
Preparation of Suppositories

Opening A Suppository Mold

The suppository mixture is poured into the cavities of a closed mold. When the suppository mixture has congealed, the excess mass is removed from the top surface of the mold and the mold is separated into the two halves.
An efficient way to separate the mold is to remove the wing nuts or loosen the centered screw and place the mold so that the posts rest on the table top.
Then apply a downward pressure only on the bottom half of the mold.
A knife or spatula should not be used to pry the two halves apart. This will damage the matching mold faces which have been accurately machined to give a tight seal.

 

Suppository shells can be opened by peeling apart the two tabs at the bottom of the shell.