The Pharmaceutics and Compounding Laboratory
Triturations and Aliquots

Trituration Method

A trituration is a dilution of a potent drug powder with an inert diluent powder, usually lactose, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.

Using ratio and proportion, we can determine the weight of drug and lactose required to make the trituration as well as the weight of the aliquot to be used to fill the prescription.

(A) Weight of drug in trituration = (C) Weight of drug in aliquot (B) Weight of trituration (D) Weight of aliquot

Keep in mind that any substance that must be weighed on the balance drug (A), lactose (B-A), and aliquot (D) must be at least 120 mg.

Lactose is the most commonly used diluent in solid dosage form pharmaceuticals such as powders, tablets and capsules. Some of the reasons included its extremely low incidence of side effects, ready availability, and low cost.

Example: Make 10 capsules, each containing 0.6 mg Atropine Sulfate and each weighing a total of 200 mg.

Make Trituration

1. Total weight atropine sulfate required (this is C in the proportion)

    0.6 mg/capsule x 10 capsules = 6 mg

2. Select some multiple of 6 mg that can be weighed with the desired degree of accuracy. (this is A in the proportion) (e.g. select multiple= 20)

    6 mg x 20 = 120 mg atropine sulfate

3. Select the size of the aliquot portion to be taken to contain the 6 mg of drug. (this is D in the proportion)

    Select 120 mg aliquot

4. Since we now have A, C, and D in our formula, we can solve for B(trituration weight).

    120 mg atropine sulfate = 6 mg atropine sulfate x mg trituration 120mg aliquot x = 2400 mg trituration (drug + diluent)

[Note: this should be the multiple (20) x the weight of the aliquot (120 mg)]

5. Determine the weight of diluent (lactose) required to prepare the trituration by subtracting the weight of atropine sulfate from the trituration weight.

    2400 mg trituration - 120 mg atropine sulfate = 2280 mg lactose

6. Fill Rx:

Determine the weight of lactose which must be added to the aliquot portion of trituration to complete the prescription, so that each capsule weighs 200 mg.

    200 mg/capsule x 10 capsules = 2000 mg (drug + lactose) 2000 mg - 120 mg aliquot = 1880 mg lactose

After the necessary calculations are completed, the trituration is prepared using the following steps:

  1. weigh a suitable amount of drug (at least 120 mg), and reduce it to a fine powder in a mortar (i.e., triturate it);
  2. weigh a suitable amount of diluent;
  3. mix the drug and diluent by geometric dilution and;
  4. weigh an aliquot of the trituration containing the desired weight of drug.

Video View a video demonstration on geometric dilution

Hence the compounding procedure for this product is as follows:

  • Weigh 120 mg atropine sulfate and triturate to a fine powder
  • Weigh 2280 mg lactose
  • Mix atropine sulfate and lactose by geometric dilution
  • Remove 120 mg of the trituration (contains 6 mg atropine sulfate)
    (Hint: save left over trituration for refills)

  • Weigh 1880 mg lactose and mix with 120 mg aliquot by geometric dilution
  • Prepare capsules weighing 200 mg each