The Pharmaceutics and Compounding Laboratory
Triturations and Aliquots

Laboratory Procedure

I. Powder Triturations

When mixing a small amount of a drug with a large amount of another ingredient or diluent, the process of geometric dilution is used. In this method the drug present in smaller quantity is placed in the mortar with an equal amount of the other ingredient. The two materials are triturated until they are well mixed. Then, an equal amount of the diluent is again added to the mixture, and trituration is repeated until they are intimately mixed. This procedure is repeated until all the powders have been combined and thoroughly mixed.

1.


                  Mel Batost, MD            Rx# 51301

                  123 Upendown Rd.

                  Nowhere, NC 27000 



Phone: 555-1234                         DEA # AH0079411 



Name: Stan Dupp                          Date:  Today 

Address:  123 Main Street, Chapel Hill   Phone: 555-1234 



Rx

        Activated Charcoal      25 mg 

        Lactose qs              10 g

        Mft powder 



        Sig: Mix contents in 1 oz. H2O prn nausea 

        No Refill



                                                        

   Product selection permitted      Dispense as written 

 

Show calculations for preparing a trituration and filling the prescription.

 

 

2.


                   Mel Batost, MD             Rx# 51302

                   123 Upendown Rd.

                   Nowhere, NC 27000 



Phone: 555-1234                          DEA # AH0079411



Name: Stan Dupp                          Date:  Today 

Address:  123 Main Street, Chapel Hill   Phone: 555-1234 



Rx

        Amaranth        6 mg

        Lactose qs      36 g

        Mft powder 



        Sig: Put 1 tsp in 8 oz. H2O as directed prn 

        2 Refills

                                                      

   Product selection permitted     Dispense as written 

Bulk density of lactose is 1.53

Show calculations for preparing a trituration and filling the prescription.

 

 

3.


                    Mel Batost, MD          Rx# 51303

                    123 Upendown Rd.

                    Nowhere, NC 27000 



Phone: 555-1234                       DEA # AH0079411 



Name: Stan Dupp                        Date:  Today 

Address:  123 Main Street, Chapel Hill Phone: 555-1234



Rx

   Salicylic acid          2 mg 

   Lactose qs              6 g 

   Mft powder



   Sig: Dissolve contents in pint of H2O and use as

        directed. 

   No Refill 



                                                     

   Product selection permitted    Dispense as written 

 

Show calculations for preparing a trituration and filling the prescription.

 

 

Analysis of product: Take 0.4 gram of the salicylic acid product, dilute to 10 ml with 0.1 NaOH, and measure the absorbance on the spectrophotometer at 310 nm using UV grade cuvettes. Record the absorbance.

Absorbance___________

 

II. Liquid Aliquot

Use the liquid aliquot method to prepare, label and dispense the following prescription.


                     Mel Batost, MD          Rx# 51304

                     123 Upendown Rd. 

                     Nowhere, NC 27000 



Phone: 555-1234                          DEA # AH0079411



Name: Stan Dupp                          Date:  Today 

Address:  123 Main Street, Chapel Hill   Phone: 555-1234



Rx

        Amaranth                0.0075% 

        Aqua Dist. qs ad.       O i 



        Sig: Put 1 tsp in baby's formula prn.

        No Refill



                                                         

   Product selection permitted       Dispense as written 

1. Show calculations:

Amaranth _____________________g (to be weighed on Rx balance)

Distilled water q.s. ______________ml (volume of solution)

Aliquot volume _________________ml

Distilled water q.s. ______________ml (to prepare final Rx product)

2. Compounding Procedure

 

 

3. Analysis of product. Take 5 mls of your product, and add 15 mls of distilled water. Mix well. Read the absorbance on the spectrophotometer at 520 nm using standard cuvettes. Record the absorbance.

Absorbance________________