Laboratory Procedure
I. Powder Triturations
When mixing a small amount of a drug with a large amount of another
ingredient or diluent, the process of geometric dilution is used.
In this method the drug present in smaller quantity is placed in the mortar
with an equal amount of the other ingredient. The two materials are triturated
until they are well mixed. Then, an equal amount of the diluent is again
added to the mixture, and trituration is repeated until they are intimately
mixed. This procedure is repeated until all the powders have been combined
and thoroughly mixed.
1.
Mel Batost, MD Rx# 51301
123 Upendown Rd.
Nowhere, NC 27000
Phone: 555-1234 DEA # AH0079411
Name: Stan Dupp Date: Today
Address: 123 Main Street, Chapel Hill Phone: 555-1234
Rx
Activated Charcoal 25 mg
Lactose qs 10 g
Mft powder
Sig: Mix contents in 1 oz. H2O prn nausea
No Refill
Product selection permitted Dispense as written
|
Show calculations for preparing a trituration and filling the prescription.
2.
Mel Batost, MD Rx# 51302
123 Upendown Rd.
Nowhere, NC 27000
Phone: 555-1234 DEA # AH0079411
Name: Stan Dupp Date: Today
Address: 123 Main Street, Chapel Hill Phone: 555-1234
Rx
Amaranth 6 mg
Lactose qs 36 g
Mft powder
Sig: Put 1 tsp in 8 oz. H2O as directed prn
2 Refills
Product selection permitted Dispense as written
|
Bulk density of lactose is 1.53
Show calculations for preparing a trituration and filling the prescription.
3.
Mel Batost, MD Rx# 51303
123 Upendown Rd.
Nowhere, NC 27000
Phone: 555-1234 DEA # AH0079411
Name: Stan Dupp Date: Today
Address: 123 Main Street, Chapel Hill Phone: 555-1234
Rx
Salicylic acid 2 mg
Lactose qs 6 g
Mft powder
Sig: Dissolve contents in pint of H2O and use as
directed.
No Refill
Product selection permitted Dispense as written
|
Show calculations for preparing a trituration and filling the prescription.
Analysis of product: Take 0.4 gram of the salicylic acid product, dilute to
10 ml with 0.1 NaOH, and measure the absorbance on the spectrophotometer at
310 nm using UV grade cuvettes. Record the absorbance.
Absorbance___________
II. Liquid Aliquot
Use the liquid aliquot method to prepare, label and dispense the
following prescription.
Mel Batost, MD Rx# 51304
123 Upendown Rd.
Nowhere, NC 27000
Phone: 555-1234 DEA # AH0079411
Name: Stan Dupp Date: Today
Address: 123 Main Street, Chapel Hill Phone: 555-1234
Rx
Amaranth 0.0075%
Aqua Dist. qs ad. O i
Sig: Put 1 tsp in baby's formula prn.
No Refill
Product selection permitted Dispense as written
|
1. Show calculations:
Amaranth _____________________g (to be weighed on Rx balance)
Distilled water q.s. ______________ml (volume of solution)
Aliquot volume _________________ml
Distilled water q.s. ______________ml (to prepare final Rx product)
2. Compounding Procedure
3. Analysis of product. Take 5 mls of your product, and add 15 mls of distilled
water. Mix well. Read the absorbance on the spectrophotometer at 520 nm using
standard cuvettes. Record the absorbance.
Absorbance________________