The Pharmaceutics and Compounding Laboratory
Pharmaceutical Solutions I:
Simple, Saturated, Syrups

Laboratory Procedures

1. Preparation of a simple solution. Prepare, label, and dispense the following prescription.

                   Jacquelyn Hyde, MD        Rx# 51601
                   123 Upendown Rd.
                   Nowhere, NC 27000
Phone:  555-1234                        DEA# AH0079411

Name:   Pat Annsir                   Date:   Today  
Address:  123 Della Street           Phone: 555-5678

Rx
      Sodium citrate dihydrate       1N
      Citric acid anhydrous          1N
      Aqua. dist. q.s. ad            3 fl. oz.

      Sig: i tsp diluted in juice or water p.c. and h.s.
      Refills: 1

                                                    
  Product selection permitted    Dispense as written

 

Determine the pH of the final solution.

Video View a video demonstration on how to use a pH meter


2. Preparation of a saturated solution. Using the formula for SSKI provided in Remington's, prepare, label, and dispense the following prescription. Calibrate a dropper to deliver the prescribed amount of medication; label dose in drops.

                   Jacquelyn Hyde, MD       Rx# 51602
                   123 Upendown Rd.
                   Nowhere, NC 27000
Phone:  555-1234                       DEA# AH0079411

Name:  Luce Morals                   Date:   Today  
Address:  123 Jackla Lane            Phone: 555-5678

Rx
        SSKI            20 ml

        Sig:  0.25 ml q.i.d.
        Refills:  2

                                                    
  Product selection permitted    Dispense as written

Video View a video demonstration on how to calibrate a dropper

3. Preparation of a simple solution from commercial tablets. Compound the following prescription, using commercially prepared tablets, each containing 0.2 mg Clonidine HCl.

                   Mel Batost, MD        Rx# 51603
                   123 Upendown Rd.
                   Nowhere, NC 27000

Phone:  555-1234                    DEA# AH0079411

Name:  Lee Mealone (Age 2 mo.)      Date:  Today  
Address:  321 Memory Lane           Phone: 555-1234

Rx
        Clonidine HCL           1.5 mg %
        Aqua. Dist. q.s. ad.    50 ml

        Sig:  0.03 mg p.o. q6h
        no refill

                                                  
 Product selection permitted   Dispense as written

 

4. Preparation of Simple Syrup. Using the formulation provided in Remington's, prepare 100 ml of simple syrup by the "solution with heat" method. Label Rx 51604, and put only "Simple Syrup," your name, and the date of preparation.

5. Preservation of guaifenesin syrup. Using alcohol as a preservative, prepare a medicinal syrup of guaifenesin. Assume that the volume occupied by the guaifenesin is negligible.

                 I. Ben Hadd, MD        Rx# 51605
                 123 Upendown Rd.
                 Nowhere, NC 27000

Phone:  555-1234                   DEA# AH0079411

Name:  Cindy Rella                 Date:   Today  
Address: 123 Jackla Lane           Phone: 555-5678

Rx
        Guaifenesin               2%
        Alcohol, USP              q.s.
        Flavoring agent of choice q.s.
        Purified water            q.s. ad 100 ml
        M.ft. syrup

        Sig: 1-2 tsp. q4-6 h, p.r.n.
        Refills: 2

                                                  
 Product selection permitted   Dispense as written

Laboratory Data

Calculations and compounding procedures should be ready for TAs to check at the beginning of lab!

1. Prescription #51601: Preparation of a simple solution

      Sodium Citrate dihydrate _______________________ g

      Citric Acid (anhydrous) ________________________ g

      Distilled Water q.s. ___________________________ ml

      Calculations:

      Compounding Procedure:

      Therapeutic use:_________________________

      pH of final product:___________

      Inspection of final product:________

2. Prescription #51602: Preparation of a saturated solution

      KI ______________ g

      Distilled water, q.s. _____________ml

      Calibrated dropper: 2 ml =______ drops; drops per 0.25 ml dose =______ drops

      Calculations:

      Compounding Procedure:

      Therapeutic use:__________________

      Inspection of final product:_______

3. Prescription #51603: Preparation of simple solution from commercial tablets

      Clonidine HCl 0.2 mg/tablet __________ tablets

      Distilled water q.s ___________ ml

      Calculations:

      Compounding Procedure:

      Therapeutic use:_______________

      Inspection of final product:________

4. Preparation of Simple Syrup: (Label #51604)

      Sucrose_________ g

      Distilled water___________ ml

      Compounding Procedure:

      Inspection of final product:________________

5. Prescription #51605: Preparation of guaifenesin syrup

      Guaifenesin __________ g

      Alcohol USP __________ ml

      Flavoring agent_______ ml

      Therapeutic use: __________________

      Compounding Procedure:

      Inspection of final product:______________