The Pharmaceutics and Compounding Laboratory
Pharmaceutical Solutions II:
Nonaqueous Solutions

Laboratory Procedure

I. Laboratory Preparation and Data
A.

                    Jacquelyn Hyde, MD      Rx# 51701
                    123 Upendown Rd. 
                    Nowhere, NC  27000
Phone:  555-1234                       DEA# AH0079411

Name:   Pat Annsir                 Date:  Today 
Address: 123 Della Street          Phone:  555-5678 

Rx
   Terpin Hydrate Elixir  120 ml
   
   Sig:  i tsp diluted in juice or water p.c. and h.s.
   Refills: 1 

       
  Product selection permitted     Dispense as written

      1. Show formula and calculations. (See page 977)

      2. Describe the method of preparation.

      3. Therapeutic Use_______________________

      4. Final Product_________________________

B.

  	                        Rx# 51702
                           Date:  Today 
  
Rx
   Compound Orange Spirit    60 ml

   Sig:  Use as stock solution

      1. Show formula and calculations.

      2. Describe the method of preparation.

      3. Therapeutic Use_______________________

      4. Final Product_________________________

C.

                 Jacquelyn Hyde, MD        Rx# 51703 
                 123 Upendown Rd.
                 Nowhere, NC  27000   
Phone:  555-1234                     DEA# AH0079411

Name:  Pat Annsir                   Date:  Today 
Address:  123 Della Street          Phone: 555-5678 

Rx 
   Aromatic Elixir   4 oz.

   Sig: i tsp diluted in juice or water p.c. and h.s.
   Refills: 1
      
   Product selection permitted   Dispense as written

      1. Show formula and calculations.

      2. Describe the method of preparation.

      3. Therapeutic Use_______________________

      4. Final Product_________________________

D.

Video View a video demonstration on how to filter a solution

		               Rx# 51704
                             Date:  Today 
  
Rx
    Low Alcoholic Elixir      120 ml

    Sig: Use prn as pharmaceutical solvent

      1. Show formula and calculations.

      2. Describe the method of preparation.

      3. Therapeutic Use_______________________

      4. Final Product_________________________

E.

                               Rx# 51705
                             Date:  Today 

Rx
    High Alcoholic Elixir    120 ml

    Sig: Use prn

      1. Show formula and calculations.

      2. Describe the method of preparation.

      3. Therapeutic Use_______________________

      4. Final Product_________________________

F. Take 30 ml of Terpin Hydrate Elixir and divide into 5-ml portions and place in test tubes. Add measured volumes of water to the test tubes to yield 10%, 20%, 30%, 40%, 50%, and 60% water solutions in Terpin Hydrate Elixir and determine to what extent the alcohol content may be reduced and still maintain a clear solution.

Adjustment of Iso-Alcoholic Elixir    
     
Low-alcoholic Elixir High-alcoholic Elixir Suitable as vehicle for preparations of the following alcohol strengths
Undiluted None 0-10%
4 volumes 1 volume 10-20%
3 volumes 1 volume 20-30%
2 volumes 1 volume 30-40%
1 volume 1 volume 40-50%
1 volume 2 volumes 50-60%
1 volume 3 volumes 60-70%
None 70% or more

Ref: 15th Remington's, p. 1240                                 

 
    LAE (ml) HAE (ml) Alcohol Strengths
2.0 ml B.T. 12 - 0-10%
2.0 ml B.T. 9.6 2.4 10-20%
2.0 ml B.T. 9.0 3.0 20-30%
2.0 ml B.T. 8.0 4.0 30-40%
2.0 ml B.T. 6.0 6.0 40-50%
2.0 ml B.T. 4 8.0 50-60%

G. Add 2.0 ml of Belladonna Tincture U.S.P. to 12 ml of vehicles of different alcohol strengths and record your observations.