The Pharmaceutics and Compounding Laboratory
Chemical Kinetics

Learning Objectives

Upon completion of this exercise, you should be able to:

  • Describe the rationale and techniques involved in accelerated stability testing. Explain how data at elevated temperatures is related to stability of the product at room temperature.
  • Differentiate between zero, first, and second order reactions and reactions rates.
  • Given drug degradation data for a compound, and the first order rate equation, construct an Arrhenius plot and determine:
    • the activation energy for the degradation reaction.
    • the first order rate constant for the degradation reaction at 25°C.
    • an appropriate shelf-life for the product (usually T90 at 25°C).